Cytotoxicity of VEGF(121)/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2

BACKGROUND: The fusion protein VEGF(121)/rGel composed of the growth factor VEGF(121 )and the plant toxin gelonin targets the tumor neovasculature and exerts impressive anti-vascular effects. We have previously shown that VEGF(121)/rGel is cytotoxic to endothelial cells overexpressing VEGFR-2 but no...

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Autors principals: Mohamedali, Khalid A, Ran, Sophia, Gomez-Manzano, Candelaria, Ramdas, Latha, Xu, Jing, Kim, Sehoon, Cheung, Lawrence H, Hittelman, Walter N, Zhang, Wei, Waltenberger, Johannes, Thorpe, Philip E, Rosenblum, Michael G
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176242/
https://ncbi.nlm.nih.gov/pubmed/21849059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-358
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