Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer

BACKGROUND: Infection with high risk Human Papilloma Virus (HPV) is associated with cancer of the cervix, vagina, penis, vulva, anus and some cases of head and neck carcinomas. The HPV derived oncoproteins E6 and E7 are constitutively expressed in tumor cells and therefore potential targets for T ce...

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Main Authors: Scholten, Kirsten BJ, Turksma, Annelies W, Ruizendaal, Janneke J, van den Hende, Muriel, van der Burg, Sjoerd H, Heemskerk, Mirjam HM, Meijer, Chris JLM, Hooijberg, Erik
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176193/
https://ncbi.nlm.nih.gov/pubmed/21892941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-147
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