The α7-nicotinic Acetylcholine Receptor and MMP-2/-9 Pathway Mediate the Proangiogenic Effect of Nicotine in Human Retinal Endothelial Cells

PURPOSE. Nicotine, the active component of cigarette smoke, has been found to stimulate angiogenesis in several experimental systems. In this study, the Matrigel duplex assay (Matrigel; BD Biosciences, Franklin Lakes, NJ) and the rat retinal explant assay were used to explore the molecular mechanism...

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主要な著者: Dom, Aaron M., Buckley, Adam W., Brown, Kathleen C., Egleton, Richard D., Marcelo, Aileen J., Proper, Nancy A., Weller, Donald E., Shah, Yashoni H., Lau, Jamie K., Dasgupta, Piyali
フォーマット: Artigo
言語:Inglês
出版事項: Association for Research in Vision and Ophthalmology, Inc. 2011
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175965/
https://ncbi.nlm.nih.gov/pubmed/20554619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5461
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