The α7-nicotinic Acetylcholine Receptor and MMP-2/-9 Pathway Mediate the Proangiogenic Effect of Nicotine in Human Retinal Endothelial Cells

PURPOSE. Nicotine, the active component of cigarette smoke, has been found to stimulate angiogenesis in several experimental systems. In this study, the Matrigel duplex assay (Matrigel; BD Biosciences, Franklin Lakes, NJ) and the rat retinal explant assay were used to explore the molecular mechanism...

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Main Authors: Dom, Aaron M., Buckley, Adam W., Brown, Kathleen C., Egleton, Richard D., Marcelo, Aileen J., Proper, Nancy A., Weller, Donald E., Shah, Yashoni H., Lau, Jamie K., Dasgupta, Piyali
格式: Artigo
語言:Inglês
出版: Association for Research in Vision and Ophthalmology, Inc. 2011
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175965/
https://ncbi.nlm.nih.gov/pubmed/20554619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5461
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