The α7-nicotinic Acetylcholine Receptor and MMP-2/-9 Pathway Mediate the Proangiogenic Effect of Nicotine in Human Retinal Endothelial Cells

PURPOSE. Nicotine, the active component of cigarette smoke, has been found to stimulate angiogenesis in several experimental systems. In this study, the Matrigel duplex assay (Matrigel; BD Biosciences, Franklin Lakes, NJ) and the rat retinal explant assay were used to explore the molecular mechanism...

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Detalhes bibliográficos
Main Authors: Dom, Aaron M., Buckley, Adam W., Brown, Kathleen C., Egleton, Richard D., Marcelo, Aileen J., Proper, Nancy A., Weller, Donald E., Shah, Yashoni H., Lau, Jamie K., Dasgupta, Piyali
Formato: Artigo
Idioma:Inglês
Publicado em: Association for Research in Vision and Ophthalmology, Inc. 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175965/
https://ncbi.nlm.nih.gov/pubmed/20554619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5461
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