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Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta

A series of structurally simple bibenzyl-diol and stilbene-diol core molecules, structural analogs of the well-known hexestrol and diethylstilbestrol non-steroidal estrogens, were prepared and evaluated as estrogen receptor (ER) subtype-selective ligands. Analysis of their ERα and ERβ binding showed...

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Detalhes bibliográficos
Main Authors: Waibel, Michael, De Angelis, Meri, Stossi, Fabio, Kieser, Karen J., Carlson, Kathryn E., Katzenellenbogen, Benita S., Katzenellenbogen, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175689/
https://ncbi.nlm.nih.gov/pubmed/19286283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2009.02.006
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