Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa–Induced Lung Injury in Mice

Inhibition of the small GTPase RhoA attenuates the development of pulmonary edema and restores positive alveolar fluid clearance in a murine model of Pseudomonas aeruginosa pneumonia. Activated protein C (aPC) blocks the development of an unfavorably low ratio of small GTPase Rac1/RhoA activity in l...

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Autori principali: Bir, Nastasha, Lafargue, Mathieu, Howard, Marybeth, Goolaerts, Arnaud, Roux, Jeremie, Carles, Michel, Cohen, Mitchell J., Iles, Karen E., Fernández, José A., Griffin, John H., Pittet, Jean-Francois
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175583/
https://ncbi.nlm.nih.gov/pubmed/21257925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2010-0397OC
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