Association of Common Variants in the Human Eyes Shut Ortholog, EYS, with Statin-Induced Myopathy: Evidence for Additional Functions of EYS

INTRODUCTION: Of nearly 38 million people in the U.S. receiving statin therapy, 0.1–0.5% experience severe or life-threatening myopathic side effects. METHODS: We performed a genome-wide association study (GWAS) in patients with severe statin myopathy versus a statin-tolerant group to identify genet...

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Main Authors: Isackson, Paul J., Ochs-Balcom, Heather M., Ma, Changxing, Harley, John B., Peltier, Wendy, Tarnopolsky, Mark, Sripathi, Naganand, Wortmann, Robert L., Simmons, Zachary, Wilson, Jon D., Smith, Stephen A., Barboi, Alexandru, Fine, Edward, Baer, Alan, Baker, Steven, Kaufman, Kenneth, Cobb, Beth, Kilpatrick, Jeffrey R., Vladutiu, Georgirene D.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175321/
https://ncbi.nlm.nih.gov/pubmed/21826682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mus.22115
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