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Exposed Hydrophobic Residues in Human Immunodeficiency Virus Type 1 Vpr Helix-1 Are Important for Cell Cycle Arrest and Cell Death

The human immunodeficiency virus type 1 (HIV-1) accessory protein viral protein R (Vpr) is a major determinant for virus-induced G2/M cell cycle arrest and cytopathicity. Vpr is thought to perform these functions through the interaction with partner proteins. The NMR structure of Vpr revealed solven...

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Bibliografiske detaljer
Main Authors: Barnitz, R. Anthony, Chaigne-Delalande, Benjamin, Bolton, Diane L., Lenardo, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174981/
https://ncbi.nlm.nih.gov/pubmed/21949789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024924
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