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Vpr Cytopathicity Independent of G(2)/M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4(+) T Cells

The mechanism of CD4(+) T-cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected individuals remains unknown, although mounting evidence suggests that direct viral cytopathicity contributes to this loss. The HIV-1 Vpr accessory protein causes cell death and arrests cells in the G(2)/...

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Autors principals: Bolton, Diane L., Lenardo, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951439/
https://ncbi.nlm.nih.gov/pubmed/17553871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00122-07
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