Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity

BACKGROUND: Acute brain injury is an important health problem. Given the critical position of caspase 8 at the crossroads of cell death pathways, we generated a new viable mouse line (Ncasp8 (−/−)), in which the gene encoding caspase 8 was selectively deleted in neurons by cre-lox system. METHODOLOG...

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Detalhes bibliográficos
Main Authors: Krajewska, Maryla, You, Zerong, Rong, Juan, Kress, Christina, Huang, Xianshu, Yang, Jinsheng, Kyoda, Tiffany, Leyva, Ricardo, Banares, Steven, Hu, Yue, Sze, Chia-Hung, Whalen, Michael J., Salmena, Leonardo, Hakem, Razqallah, Head, Brian P., Reed, John C., Krajewski, Stan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174961/
https://ncbi.nlm.nih.gov/pubmed/21957448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024341
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