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The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation in response to growth factor and nutrient signaling. Consequently, this kinase is implicated in metabolic diseases including cancer and diabetes, so there is great interest in understanding the complete...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Beatrice T., Ducker, Gregory S., Barczak, Andrea J., Barbeau, Rebecca, Erle, David J., Shokat, Kevan M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174577/
https://ncbi.nlm.nih.gov/pubmed/21876130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103746108
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