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Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC)

Sodium reabsorption via the epithelial Na(+) channel (ENaC) in the aldosterone-sensitive distal nephron plays a central role in the regulation of body fluid volume. Previous studies have indicated that arachidonic acid (AA) and its metabolite 11,12-EET but not other regioisomers of EETs inhibit ENaC...

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Autori principali: Pavlov, Tengis S., Ilatovskaya, Daria V., Levchenko, Vladislav, Mattson, David L., Roman, Richard J., Staruschenko, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174560/
https://ncbi.nlm.nih.gov/pubmed/21697242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00597.2010
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