Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes

Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify potent—albeit not always selective—kinase inhibitors. Herein, in an effort to inv...

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Detalhes bibliográficos
Main Authors: Child, Emma S., Georgiades, Savvas N., Rose, Kirsten N., Stafford, Verity S., Patel, Chirag B. K., Steinke, Joachim H. G., Mann, David J., Vilar, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174280/
https://ncbi.nlm.nih.gov/pubmed/22368708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12154-011-0059-5
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