Protein-Protein Interactions in Crystals of the Human Receptor-Type Protein Tyrosine Phosphatase ICA512 Ectodomain

ICA512 (or IA-2) is a transmembrane protein-tyrosine phosphatase located in secretory granules of neuroendocrine cells. Initially, it was identified as one of the main antigens of autoimmune diabetes. Later, it was found that during insulin secretion, the cytoplasmic domain of ICA512 is cleaved and...

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Main Authors: Primo, María E., Jakoncic, Jean, Noguera, Martín E., Risso, Valeria A., Sosa, Laura, Sica, Mauricio P., Solimena, Michele, Poskus, Edgardo, Ermácora, Mario R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174154/
https://ncbi.nlm.nih.gov/pubmed/21935384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024191
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