The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

Inactivation of the TCA cycle enzyme, fumarate hydratase (FH), drives a metabolic shift to aerobic glycolysis in FH-deficient kidney tumors and cell lines from patients with hereditary leiomyomatosis renal cell cancer (HLRCC), resulting in decreased levels of AMP-activated kinase (AMPK) and p53 tumo...

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Bibliografische gegevens
Hoofdauteurs: Tong, Wing-Hang, Sourbier, Carole, Kovtunovych, Gennady, Jeong, Suh Young, Vira, Manish, Ghosh, Manik, Romero, Vladimir Valera, Sougrat, Rachid, Vaulont, Sophie, Viollet, Benoit, Kim, Yeong-Sang, Lee, Sunmin, Trepel, Jane, Srinivasan, Ramaprasad, Bratslavsky, Gennady, Yang, Youfeng, Linehan, W. Marston, Rouault, Tracey A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174047/
https://ncbi.nlm.nih.gov/pubmed/21907923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.07.018
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