Differential Effect of Calsequestrin Ablation on Structure and Function of Fast and Slow Skeletal Muscle Fibers

We compared structure and function of EDL and Soleus muscles in adult (4–6 m) mice lacking both Calsequestrin (CASQ) isoforms, the main SR Ca(2+)-binding proteins. Lack of CASQ induced ultrastructural alterations in ~30% of Soleus fibers, but not in EDL. Twitch time parameters were prolonged in both...

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Bibliografiske detaljer
Main Authors: Paolini, Cecilia, Quarta, Marco, D'Onofrio, Laura, Reggiani, Carlo, Protasi, Feliciano
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173739/
https://ncbi.nlm.nih.gov/pubmed/21941434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/634075
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