Critical Role of TCF-1 in Repression of the IL-17 Gene

Overwhelming activation of IL-17, a gene involved in inflammation, leads to exaggerated Th17 responses associated with numerous autoimmune conditions, such as experimental autoimmune encephalomyelitis (EAE). Here we show that TCF-1 is a critical factor to repress IL-17 gene locus by chromatin modifi...

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Bibliografiske detaljer
Main Authors: Ma, Jian, Wang, Ruiqing, Fang, Xianfeng, Ding, Yan, Sun, Zuoming
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173465/
https://ncbi.nlm.nih.gov/pubmed/21935461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024768
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