α-Phenyl-N-tert-butylnitrone (PBN) Prevents Light-induced Degeneration of the Retina by Inhibiting RPE65 Protein Isomerohydrolase Activity

α-Phenyl-N-tert-butylnitrone (PBN), a free radical spin trap, has been shown previously to protect retinas against light-induced neurodegeneration, but the mechanism of protection is not known. Here we report that PBN-mediated retinal protection probably occurs by slowing down the rate of rhodopsin...

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Autori principali: Mandal, Md Nawajes A., Moiseyev, Gennadiy P., Elliott, Michael H., Kasus-Jacobi, Anne, Li, Xiaoman, Chen, Hui, Zheng, Lixin, Nikolaeva, Olga, Floyd, Robert A., Ma, Jian-xing, Anderson, Robert E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173208/
https://ncbi.nlm.nih.gov/pubmed/21785167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255877
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