Interaction between the Human Mitochondrial Import Receptors Tom20 and Tom70 in Vitro Suggests a Chaperone Displacement Mechanism

The mitochondrial import receptor Tom70 contains a tetratricopeptide repeat (TPR) clamp domain, which allows the receptor to interact with the molecular chaperones, Hsc70/Hsp70 and Hsp90. Preprotein recognition by Tom70, a critical step to initiate import, is dependent on these cytosolic chaperones....

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Detalhes bibliográficos
Main Authors: Fan, Anna C. Y., Kozlov, Guennadi, Hoegl, Annabelle, Marcellus, Richard C., Wong, Michael J. H., Gehring, Kalle, Young, Jason C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173181/
https://ncbi.nlm.nih.gov/pubmed/21771790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280446
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