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Structural Basis of Binding of P-body-associated Proteins GW182 and Ataxin-2 by the Mlle Domain of Poly(A)-binding Protein

Poly(A)-binding protein (PABPC1) is involved in multiple aspects of mRNA processing and translation. It is a component of RNA stress granules and binds the RNA-induced silencing complex to promote degradation of silenced mRNAs. Here, we report the crystal structures of the C-terminal Mlle (or PABC)...

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Autori principali: Kozlov, Guennadi, Safaee, Nozhat, Rosenauer, Angelika, Gehring, Kalle
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859521/
https://ncbi.nlm.nih.gov/pubmed/20181956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089540
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