Lysine N(ζ)-Decarboxylation Switch and Activation of the β-Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus

The integral membrane protein BlaR1 of methicillin-resistant Staphylococcus aureus senses the presence of β-lactam antibiotics in the milieu and transduces the information to the cytoplasm, where the biochemical events that unleash induction of antibiotic resistance mechanisms take place. We report...

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Detalhes bibliográficos
Main Authors: Borbulevych, Oleg, Kumarasiri, Malika, Wilson, Brian, Llarrull, Leticia I., Lee, Mijoon, Hesek, Dusan, Shi, Qicun, Peng, Jeffrey, Baker, Brian M., Mobashery, Shahriar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173090/
https://ncbi.nlm.nih.gov/pubmed/21775440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252189
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