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Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production

The retinoic acid-related orphan nuclear receptor γt (RORγt)/RORγ2 is well known as a master regulator of interleukin 17 (IL-17)-producing helper T (Th17) cell development. To develop a therapeutic agent against Th17-mediated autoimmune diseases, we screened chemical compounds and successfully found...

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Detalhes bibliográficos
Main Authors: Fujita-Sato, Saori, Ito, Shuichiro, Isobe, Takashi, Ohyama, Takao, Wakabayashi, Kenji, Morishita, Kaoru, Ando, Osamu, Isono, Fujio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173075/
https://ncbi.nlm.nih.gov/pubmed/21733845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254003
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