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DNA Methylation in the Arginase–Nitric Oxide Synthase Pathway Is Associated with Exhaled Nitric Oxide in Children with Asthma

Rationale: Genetic variation in arginase (ARG) and nitric oxide synthase (NOS) has been associated with exhaled nitric oxide (FeNO) levels in children. Little is known about whether epigenetic variation in these genes modulates FeNO. Objectives: To evaluate whether DNA methylation in ARG and NOS gen...

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Autors principals: Breton, Carrie V., Byun, Hyang-Min, Wang, Xinhui, Salam, Muhammad T., Siegmund, Kim, Gilliland, Frank D.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172885/
https://ncbi.nlm.nih.gov/pubmed/21512169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201012-2029OC
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