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Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations

To directly determine whether recombinational repair of double-strand breaks (DSBs) can occur between heterologous chromosomes and lead to chromosomal rearrangements in mammalian cells, we employed an ES cell system to analyze recombination between repeats on heterologous chromosomes. We found that...

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Publicat a:Genes Dev
Autors principals: Richardson, Christine, Moynahan, Mary Ellen, Jasin, Maria
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 1998
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317271/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9869637/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.24.3831
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