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Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes
Protein misfolding is a common event in living cells. Molecular chaperones not only assist protein folding; they also facilitate the degradation of misfolded polypeptides. When the intracellular degradative capacity is exceeded, juxtanuclear aggresomes are formed to sequester misfolded proteins. Des...
Wedi'i Gadw mewn:
| Prif Awduron: | , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
The American Society for Cell Biology
2011
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172255/ https://ncbi.nlm.nih.gov/pubmed/21775628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-05-0388 |
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