DNA damage activates p53 through a phosphorylation–acetylation cascade

Activation of p53-mediated transcription is a critical cellular response to DNA damage. p53 stability and site-specific DNA-binding activity and, therefore, transcriptional activity, are modulated by post-translational modifications including phosphorylation and acetylation. Here we show that p53 is...

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Main Authors: Sakaguchi, Kazuyasu, Herrera, Julio E., Saito, Shin’ichi, Miki, Toru, Bustin, Michael, Vassilev, Alex, Anderson, Carl W., Appella, Ettore
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC317174/
https://ncbi.nlm.nih.gov/pubmed/9744860
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