Impact of Apolipoprotein E ε4 and HIV on Cognition and Brain Atrophy: Antagonistic Pleiotropy and Premature Brain Aging

OBJECTIVE: The apolipoprotein E (APOE) ε4 allele may accelerate the progression of HIV disease, and increase the risk for developing HIV-associated neurocognitive disorder (HAND). Whether APOEε4 allele(s) and age may influence brain atrophy in HIV patients is unknown and was evaluated. METHODS: Auto...

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Main Authors: Chang, L., Andres, M., Sadino, J., Jiang, C.S., Nakama, H., Miller, E., Ernst, T.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171637/
https://ncbi.nlm.nih.gov/pubmed/21803164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2011.07.010
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