Structural basis of inhibition of CDK–cyclin complexes by INK4 inhibitors

The cyclin-dependent kinases 4 and 6 (Cdk4/6) that drive progression through the G(1) phase of the cell cycle play a central role in the control of cell proliferation, and CDK deregulation is a frequent event in cancer. Cdk4/6 are regulated by the D-type cyclins, which bind to CDKs and activate the...

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Pubblicato in:	Genes Dev
Autori principali:	Jeffrey, Philip D., Tong, Lily, Pavletich, Nikola P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2000
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317144/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11124804/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.851100
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