TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest
On TGF-β binding, the TGF-β receptor directly phosphorylates and activates the transcription factors Smad2/3, leading to G(1) arrest. Here, we present evidence for a second, parallel, TGF-β-dependent pathway for cell cycle arrest, achieved via inhibition of p70(s6k). TGF-β induces association of its...
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| Publicado no: | Genes Dev |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317138/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11124802/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.854200 |
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