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Mechanism for modulation of gating of connexin26-containing channels by taurine

The mechanisms of action of endogenous modulatory ligands of connexin channels are largely unknown. Previous work showed that protonated aminosulfonates (AS), notably taurine, directly and reversibly inhibit homomeric and heteromeric channels that contain Cx26, a widely distributed connexin, but not...

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Autori principali: Locke, Darren, Kieken, Fabien, Tao, Liang, Sorgen, Paul L., Harris, Andrew L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171079/
https://ncbi.nlm.nih.gov/pubmed/21844220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110634
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