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Mechanism for modulation of gating of connexin26-containing channels by taurine

The mechanisms of action of endogenous modulatory ligands of connexin channels are largely unknown. Previous work showed that protonated aminosulfonates (AS), notably taurine, directly and reversibly inhibit homomeric and heteromeric channels that contain Cx26, a widely distributed connexin, but not...

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Detalhes bibliográficos
Main Authors: Locke, Darren, Kieken, Fabien, Tao, Liang, Sorgen, Paul L., Harris, Andrew L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171079/
https://ncbi.nlm.nih.gov/pubmed/21844220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110634
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