A tick mannose-binding lectin inhibits the vertebrate complement cascade to enhance transmission of the Lyme disease agent

The Lyme disease agent, Borrelia burgdorferi, is primarily transmitted to vertebrates by Ixodes ticks. The classical and alternative complement pathways are important in Borrelia eradication by the vertebrate host. We recently identified a tick salivary protein, designated P8 that reduced complement...

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Hlavní autoři: Schuijt, Tim J., Coumou, Jeroen, Narasimhan, Sukanya, Dai, Jianfeng, DePonte, Kathleen, Wouters, Diana, Brouwer, Mieke, Oei, Anneke, Roelofs, Joris J.T.H., van Dam, Alje P., van der Poll, Tom, van ’t Veer, Cornelis, Hovius, Joppe W., Fikrig, Erol
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170916/
https://ncbi.nlm.nih.gov/pubmed/21843870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.06.010
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