A tick mannose-binding lectin inhibits the vertebrate complement cascade to enhance transmission of the Lyme disease agent

The Lyme disease agent, Borrelia burgdorferi, is primarily transmitted to vertebrates by Ixodes ticks. The classical and alternative complement pathways are important in Borrelia eradication by the vertebrate host. We recently identified a tick salivary protein, designated P8 that reduced complement...

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Detalhes bibliográficos
Main Authors: Schuijt, Tim J., Coumou, Jeroen, Narasimhan, Sukanya, Dai, Jianfeng, DePonte, Kathleen, Wouters, Diana, Brouwer, Mieke, Oei, Anneke, Roelofs, Joris J.T.H., van Dam, Alje P., van der Poll, Tom, van ’t Veer, Cornelis, Hovius, Joppe W., Fikrig, Erol
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170916/
https://ncbi.nlm.nih.gov/pubmed/21843870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.06.010
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