Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse development as well as cell growth in culture. Here, we provide evidence that ras-mediated tumorigenesis depends o...

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Detalhes bibliográficos
Main Authors: Robles, Ana I., Rodriguez-Puebla, Marcelo L., Glick, Adam B., Trempus, Carol, Hansen, Laura, Sicinski, Piotr, Tennant, Raymond W., Weinberg, Robert A., Yuspa, Stuart H., Conti, Claudio J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1998
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC317082/
https://ncbi.nlm.nih.gov/pubmed/9716400
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