Defects in transforming growth factor-β signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

Genetic inactivation of the transforming growth factor-β (TGF-β) signaling pathway can accelerate tumor progression in the mouse epidermal model of multistage carcinogenesis. By using an in vitro model of keratinocyte transformation that parallels in vivo malignant conversion to squamous cell carcin...

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Bibliographic Details
Main Authors: Glick, Adam, Popescu, Nicholas, Alexander, Valarie, Ueno, Hikaru, Bottinger, Erwin, Yuspa, Stuart H.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC24753/
https://ncbi.nlm.nih.gov/pubmed/10611318
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