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Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors
A new metal-containing scaffold for the design of protein kinase inhibitors is introduced. Key feature is a 3-(2-pyridyl)-1,8-naphthalimide “pharmacophore chelate ligand” which is designed to form two hydrogen bonds with the hinge region of the ATP-binding site and is at the same time capable of ser...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3170819/ https://ncbi.nlm.nih.gov/pubmed/21918590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/om200366r |
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