Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

The generation of synthetic compounds with exclusive target specificity is an extraordinary challenge of molecular recognition and demands novel design strategies, in particular for large and homologous protein families such as protein kinases with more than 500 members. Simple organic molecules oft...

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Detalhes bibliográficos
Main Authors: Feng, Li, Geisselbrecht, Yann, Blanck, Sebastian, Wilbuer, Alexander, Atilla-Gokcumen, G. Ekin, Filippakopoulos, Panagis, Kräling, Katja, Celik, Mehmet Ali, Harms, Klaus, Maksimoska, Jasna, Marmorstein, Ronen, Frenking, Gernot, Knapp, Stefan, Essen, Lars-Oliver, Meggers, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076536/
https://ncbi.nlm.nih.gov/pubmed/21446733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1112996
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