The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

The unfolded protein response (UPR) is a signal transduction pathway that is activated by the accumulation of unfolded proteins in the endoplasmic reticulum (ER). In Saccharomyces cerevisiae the ER transmembrane receptor, Ire1p, transmits the signal to the nucleus culminating in the transcriptional...

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Hauptverfasser: Tirasophon, Witoon, Lee, Kyungho, Callaghan, Brian, Welihinda, Ajith, Kaufman, Randal J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2000
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC317029/
https://ncbi.nlm.nih.gov/pubmed/11069889
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