Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

The checkpoint kinase Xchk1 becomes phosphorylated in Xenopus egg extracts in response to DNA replication blocks or UV-damaged DNA. Xchk1 is also required for the cell cycle delay that is induced by unreplicated or UV-damaged DNA. In this report, we have removed the Xenopus homolog of ATR (Xatr) fro...

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Pubblicato in:	Genes Dev
Autori principali:	Guo, Zijian, Kumagai, Akiko, Wang, Sophie X., Dunphy, William G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2000
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317027/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11069891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.842500
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