A zinc-binding site in the largest subunit of DNA-dependent RNA polymerase is involved in enzyme assembly

All multisubunit DNA-dependent RNA polymerases (RNAP) are zinc metalloenzymes, and at least two zinc atoms are present per enzyme molecule. RNAP residues involved in zinc binding and the functional role of zinc ions in the transcription mechanism or RNAP structure are unknown. Here, we locate four c...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Markov, Dmitriy, Naryshkina, Tatyana, Mustaev, Arkady, Severinov, Konstantin
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1999
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Research Paper
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317019/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500100/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.18.2439
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