The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

Smads regulate transcription of defined genes in response to TGF-β receptor activation, although the mechanisms of Smad-mediated transcription are not well understood. We demonstrate that the TGF-β-inducible Smad3 uses the tumor suppressor Smad4/DPC4 and CBP/p300 as transcriptional coactivators, whi...

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Pubblicato in:	Genes Dev
Autori principali:	Feng, Xin-Hua, Zhang, Ying, Wu, Rui-Yun, Derynck, Rik
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1998
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9679060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.14.2153
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