Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rβ(2) or IL-18Rα

The oncolytic adenovirus (Ad) is currently being advanced as a promising antitumor remedy as it selectively replicates in tumor cells and can transfer and amplify therapeutic genes. Interleukin (IL)-12 induces a potent antitumor effect by promoting natural killer (NK) cell and cytotoxic T cell activ...

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Detalhes bibliográficos
Main Authors: Choi, I-K, Lee, J-S, Zhang, S-N, Park, J, Lee, K-M, Sonn, C H, Yun, C-O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169807/
https://ncbi.nlm.nih.gov/pubmed/21451575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.37
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