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Gαi2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1 induced T cell functions()
RasGRP1, a Ras guanine-nucleotide exchange factor, critically mediates T cell development and function and controls immunodeficiency and autoimmunity. Here, we describe a unique mechanism of mobilization and activation of RasGRP1 in response to SDF-1, a chemokine that signals via the G protein-coupl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169754/ https://ncbi.nlm.nih.gov/pubmed/21856938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100206 |
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