A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication

Using a reconstituted DNA replication assay from yeast, we demonstrate that two kinase complexes are essential for the promotion of replication in vitro. An active Clb/Cdc28 kinase complex, or its vertebrate equivalent, is required in trans to stimulate initiation in G(1)-phase nuclei, whereas the D...

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Pubblicato in:	Genes Dev
Autori principali:	Pasero, Philippe, Duncker, Bernard P., Schwob, Etienne, Gasser, Susan M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1999
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316966/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10465792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.16.2159
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