ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Activation of NF-κB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. We report the identification and characterization of a novel intermediate in these signaling pathways that bridges TRAF6 to MEKK-1. This adapter protein, which we have...

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Библиографические подробности
Главные авторы: Kopp, Elizabeth, Medzhitov, Ruslan, Carothers, James, Xiao, Changchun, Douglas, Iris, Janeway, Charles A., Ghosh, Sankar
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 1999
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC316957/
https://ncbi.nlm.nih.gov/pubmed/10465784
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