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Structured Pathway across the Transition State for Peptide Folding Revealed by Molecular Dynamics Simulations

Small globular proteins and peptides commonly exhibit two-state folding kinetics in which the rate limiting step of folding is the surmounting of a single free energy barrier at the transition state (TS) separating the folded and the unfolded states. An intriguing question is whether the polypeptide...

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Autors principals: Thukral, Lipi, Daidone, Isabella, Smith, Jeremy C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169518/
https://ncbi.nlm.nih.gov/pubmed/21931542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002137
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