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Molecular Origin of Gerstmann-Sträussler-Scheinker Syndrome: Insight from Computer Simulation of an Amyloidogenic Prion Peptide

Prion proteins become pathogenic through misfolding. Here, we characterize the folding of a peptide consisting of residues 109–122 of the Syrian hamster prion protein (the H1 peptide) and of a more amyloidogenic A117V point mutant that leads in humans to an inheritable form of the Gerstmann-Sträussl...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Daidone, Isabella, Di Nola, Alfredo, Smith, Jeremy C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Biophysical Society 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123976/
https://ncbi.nlm.nih.gov/pubmed/21689534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.04.053
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