TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

BACKGROUND: Amyloid plaques, a pathological hallmark of Alzheimer's disease (AD), are accompanied by activated microglia. The role of activated microglia in the pathogenesis of AD remains controversial: either clearing Aβ deposits by phagocytosis or releasing proinflammatory cytokines and cytot...

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Detalhes bibliográficos
Main Authors: Song, Min, Jin, JingJi, Lim, Jeong-Eun, Kou, Jinghong, Pattanayak, Abhinandan, Rehman, Jamaal A, Kim, Hong-Duck, Tahara, Kazuki, Lalonde, Robert, Fukuchi, Ken-ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169468/
https://ncbi.nlm.nih.gov/pubmed/21827663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-92
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