Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin–proteasome system. Activation of p27 degradation is seen in proliferating cells and in many types of aggressive human carcinomas. p27 can be phosphorylated on threonine 187 by Cdks, and cyclin E/C...

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הוצא לאור ב:	Genes Dev
Principais autores:	Montagnoli, Alessia, Fiore, Francesca, Eytan, Esther, Carrano, Andrea C., Draetta, Giulio F., Hershko, Avram, Pagano, Michele
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Cold Spring Harbor Laboratory Press 1999
נושאים:	Research Paper
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316946/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10323868/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.9.1181
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